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SC and EAB provided guidance on systematic reviewing.
We hope that PRISMA can be the basis for more detailed guidance on systematic reviews of other types of research, including diagnostic accuracy and epidemiological studies.
The authors would like to thank Jo Jordan for her contribution to the search strategy used in this review and her guidance on systematic review methodology, and the reviewers for their helpful comments on the content of this manuscript.
The PRISMA guidance on systematic reviews explains how, in carrying out a systematic review, it is important "to distinguish between quality and risk of bias and to focus on evaluating and reporting the latter" [ 22].
Much of the current guidance on systematic reviews is directed towards the evaluation of effectiveness; but this differs in important ways from the methods used in assessing the safety and tolerability of an intervention.
The Cochrane Handbook for Systematic Reviews of Interventions, 21 32 which describes the Cochrane Collaboration's methodology for review conduct and reporting, is a widely cited source of guidance on systematic review and meta-analysis methodology.
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In Japan, since there has been neither comprehensive HTA nor guidance based on systematic reviews, further examinations would be required for health and clinical policy.
7 12 13 16 28–33 A range of other books or guidance documents on systematic reviews exist.
WHO/CDC technical guidance based on systematic review evidence is that, in the absence of infections, serum ferritin or serum transferrin receptor in combination with haemoglobin provides the best approach to measuring iron status in general populations [ 31].
In the document analysis we systematically checked whether the procedure provides guidance on the systematic use of research on patient preferences, and whether the search and use of research on patient preferences is mentioned in the decision making procedure.
Although the methods for conducting systematic reviews of efficacy are well established, there is much less guidance on how systematic reviews of adverse effects should be performed.
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