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In contrast, in the cochlea, absence of Prox1 disrupts stereotyped cellular organization and fiber guidance of Type II neurons apparently in a cell autonomous fashion.
These results identify a dual role of Prox1 during inner ear development; growth of the canal cristae and fiber guidance of Type II fibers along supporting cells in the cochlea.
Therefore, it may be the distribution of Plexin-A3 that accounts for the selective guidance of type I and type II SGNs.
1) The apparent expression of Nrp2 in all SGN neurons presents a challenge to understanding the selective guidance of Type I SGN afferents by Sema3F as described here.
Specific comments are detailed below: Major criticisms: 1) The apparent expression of Nrp2 in all SGN neurons presents a challenge to understanding the selective guidance of Type I SGN afferents by Sema3F as described here.
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SEC guidance of this type is not a common occurrence.
Moral guidance of this type would be expected only from someone who thinks that sneaking into little girls dressing rooms is "the funniest" thing.
Some pop musicians, of course, have studied classical or jazz and thus have a more robust harmonic/melodic/rhythmic vocabulary as part of their repertoire than others (Elton John comes to mind); as a result, they may not need assistance or guidance of that type.
Study design: Human HSC were directly injected into the peritoneal cavities of the recipient fetal goats at 45 55 days of gestation (term: 145 days) under the guidance of B-type ultrasound scan.
We hypothesized that haptic guidance of both types would improve the performance of the subjects in comparison to the control training session.
Together our results indicate that a β-catenin-dependent pathway regulates guidance of D-type axons along the AP axis (Fig. 4J).
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