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This should make it easy to quantify phenotypes in response to perturbation experiments, and thus provides a tractable model system to study neuronal guidance in response to ECM topology.
Because neuronal guidance in response to immobilized laminin has been reported to require mechanosensing through myosin activation [21], we also explored if contractility is important for neurite orientation in our system through inhibition of Rho kinase or of myosin II ATPase activity (using the Y-27632 and blebbistatin drugs).
In the Tees Valley Healthy Heart Checks (HHC) were established ahead of the national guidance, in response to recommendations made locally by the Health Inequalities National Support Team.
establishing an independent "data access committee" to review research protocols that raise significant privacy concerns (perhaps on a referral basis from RECs) and to provide general guidance in response to anticipated or existing privacy challenges.
Calcium release from internal stores and entry through TRP channels are important sources of calcium for regulating axon growth and guidance in response to environmental cues (Li et al., 2005, 2009; Shim et al., 2005).
The results presented here suggest that the stochastic fluctuation of UNC-40 outgrowth activity underlies the ability of the neuron to determine the direction of guidance in response to UNC-6.
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Furthermore, the creation of a range of gradually transitioning features with direct photopolymerization enables the tailored probing of cell contact guidance behavior in response to simultaneous physical and chemical guidance cues.
Former U.S. Attorney General Loretta Lynch issued that guidance last year in response to North Carolina passing a law, HB 2, that requires transgender people to use bathrooms that match the sex on their birth certificate.
Seema Verma, the agency's administrator, said the policy guidance came in response to requests from at least 10 states that have proposed requiring some Medicaid recipients to work or participate in activities that may include skills training, education, job search, volunteering or caregiving.
To provide such guidance, and in response to the need to develop a flexible approach for country-driven health assessments, we developed a framework using familiar methods to evaluate the impacts of climate variability and change, to identify vulnerable populations, and to assess adaptation policies and measures (Kovats et al. 2003b).
UNICEF Offices and partners will also benefit from a new Early Warning Early Action system that monitors potential emergencies as well as technical guidance in sectoral response, cluster approach modalities and business continuity planning.
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