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This article develops insight into why these cells differ in their contact guidance fidelity.
Subtle, but quantifiable alterations in myosin II regulatory light chain phosphorylation on stress fibers explain the tuning of contact guidance fidelity, separate from migration per se indicating that the contractile and adhesive state of the cell in combination with collagen organization in the tumor microenvironment determine the efficiency of migration.
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That, he said, is, "Fidelity, fidelity, fidelity".
2 This guidance recognises that intervention fidelity is underevaluated.
Interestingly, vertebrate Ret has been shown to cooperate with Ephrins to ensure high fidelity axon guidance in motor neurons by mediating attractive EphrinA reverse signaling (Kramer et al., 2006; Bonanomi et al., 2012).
Data on treatment fidelity were assessed using published guidance (18).
To facilitate a lower-risk transition from ground processing to an autonomous capability, the NASA Engineering and Safety Center NESCC) has assembled a team of experts in aerobraking and interplanetary guidance and control to develop a high-fidelity, flight-like simulation.
9 10 Unresolved debates regarding adaption of interventions, and what is meant by intervention fidelity, are discussed at length in the full guidance.
Surety bonds are normally written on principals who are acting in an independent or semi-independent capacity, such as building contractors or public officials, whereas fidelity bonds are written on employees acting under the guidance and supervision of their employer.
Stability and zero-miss distance analysis of the proposed controller is presented, and a high-fidelity numerical simulation verifies the performance of the guidance laws.
The whole guidance, navigation and control algorithm has been tested on a high-fidelity descent simulator.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com