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DOI: http://dx.doi.org/10.7554/eLife.00378.004 10.7554/eLiFigure78.005 Figure 1 figure supplement 2. vm2 muscle arm development is a guidance event independent of presynaptic specialization.
All Slit genes are also expressed in the postnatal stage (Marillat et al. 2002; Whitford et al. 2002), but the role of SLITs after the axon guidance event remains to be determined.
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"At Anglia Ruskin the team sends out vacancies on nearly a daily basis and organises guidance events and workshops for each faculty to help with the job application and recruitment process," she says.
Which guidance events are being affected has not yet been determined, but a few candidates exist.
Transcription factors that are highly conserved from Drosophila to humans have been found to be required for specific axon guidance events [1], [2], [3], [4].
These data continue to highlight the critical role Fra plays in regulating cytoskeletal dynamics during guidance events at the midline, and implicate all three molecules, Abl, Rac and Cdc42, in this process.
The molecular program that controls early guidance events of retinal axons at the optic chiasm has been described clearly.
Although the role of SLITs/ROBOs in axon guidance during development may be as expected, their roles in postnatal monkey brains, where there are no major guidance events, is as yet unclarified.
In addition to cell surface receptor genes that can directly affect cell migration and axon guidance events, our microarray analysis also identified various genes that modulate cell signalling pathways, which in turn can influence cell migration.
In future experiments it will be important to assess the role of Megf8 in other axon guidance events controlled by BMP signaling, including the ventral axonal trajectory of neurons whose cell bodies reside within the dorsal spinal cord.
Given the sequential birth order and the unique patterning of MB neurons, it is likely that specific gene cascades are required for the different guidance events that form the characteristic lobes of the MB.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com