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For Froome, the gruelling effects of the three-week ride have been exacerbated by the unrelenting hostility of the French public, who seem convinced – without producing any evidence to back their view – that Froome must be a drug cheat.
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"For some HER2 positive breast cancer patients the effect of this drug combination will be amazing and mean they can avoid chemotherapy and its gruelling side effects completely.
The ballet world was shocked and mystified by Polunin's departure, but a few weeks later the dancer told the Guardian that he had found rehearsing "very boring" and that he wanted to give up ballet by the age of 26 because the physical effects were so gruelling.
Arsenal's manager, undermined by injuries and the after-effects of Saturday's gruelling FA Cup semi-final penalty shootout win over Wigan Athletic, opted to rest Aaron Ramsey and Alex Oxlade-Chamberlain, although the former did come on as a 72nd-minute substitute.
Since then, women have competed in events as gruelling as the marathon with no ill effects.
It provides awe-inspiring insight into the amazing special effects behind an episode that was gruelling even by Game of Thrones standards.
The effects for both men are likely to be gruelling, especially Scott who will have plenty of other activities to keep him busy on the space station.
With international markets closed to Greece, and contagion threatening Portugal and Spain, European Union leaders agreed to a similar pledge after a pair of gruelling, late-night meetings on May 7th and 9th.From now on, they in effect declared, markets betting against one member of the euro zone would meet a swift response from all 16.
Interviewing Campbell is gruelling.
The training was gruelling.
Scrutiny can be gruelling.
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