Knockdown of FAK by siRNA in the human colon cancer lines HT-25 and RKO, resulted in increased paxillinpoY118 levels under suspension conditions as well as increased anchorage-independent growth, supporting the notion that FAK attenuates anchorage-independent growth by suppressing adhesion-dependent phosphorylation of paxillinY118.
One of the things that's going on is a shift in the idea of what a theatre should be - and a growth in the notion that a show doesn't always stop at the door.
Mr. Lowrie, who met Mr. Cain at a conference sponsored by the conservative Club for Growth, dismissed the notion that his own understanding of economics was limited by lack of a Ph.D. "I don't list myself as an economist," he said.
Moreover, the absence of this band in both phases of growth supports the notion that the apparently different mobility observed between lanes in Figure 1 was only an artifactual effect of the electrophoretic run.
Since the beginning of the growth period, the notion of TKM research was expanded as a substitute for Western medicine through the discovery of alternative efficacies, mechanisms of new action, and novel substances as part of a large-scale project.
Of particular interest is the observation that factors that are normally expressed within the bone marrow to specifically regulate and maintain the HSC niche are also involved in enhancing myeloma cell growth, supporting the notion that normal haematopoiesis, specifically maintenance of HSC within the bone marrow, is compromised throughout MM development and progression.
Meanwhile, the timing of recent economic growth strongly supports the notion that stimulus does, indeed, boost the economy: growth accelerated last year, as the stimulus reached its predicted peak impact, but has fallen off — just as some of us feared — as the stimulus has faded.
Forth, miR-503 suppresses tumor cell growth, consistent with the notion that suppression of CCND1 would inhibit cell growth.
Earlier this year, the IMF published a paper – Redistribution, Inequality and Growth – which challenged the notion that policymakers had to make a choice between tackling inequality and achieving faster growth.
In this section, we introduce an economic model named stochastic R&D model in economic growth [10]; for the notion of the model, see details in reference [9, 10].
