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In fact, most pediatric endocrinologists agree that no matter what age is accepted as normal for the earliest onset of puberty in girls -- 6, 7 or 8 years old -- rapid progression of breast or pubic hair development accompanied by accelerated growth, significant skeletal age advancement, neurological abnormalities or psychological disturbances mandates prompt and extensive evaluation.
Analysts said the fall in the euro area index reflected a combination of slowing global growth, significant belt-tightening in the euro area and growing concern about the escalating sovereign debt crisis.
After World War II it was chosen to be a model of modernization and a major centre of growth; significant investments in fisheries were made, and a large fish-processing plant (among the largest in the North Atlantic at the time) was built.
However, the recent realities in terms of rapid population growth, significant increase in livestock owned by the indigenous population in the Sudanian zones and the settlement of many pastoralists in the areas, imply that livestock can no longer be considered as secondary in these zones.
Indeed, whilst little variation from non-stressed conditions was observed after 24 hours growth, significant differences were observed after 7 days growth.
In RCC tumour xenografts, both VHL wild-type or mutant, IMO plus everolimus caused a potent and long-lasting cooperative antitumour activity with strong reduction of tumour growth, significant prolongation of mice survival and potent inhibition of signal transduction.
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Cable is also in position, Ms. Warner said, to translate accelerating revenue growth into significant cash-flow growth.
The economy has defied many analysts' expectations by maintaining a torrid rate of growth without significant inflation.
His comments came as Ocado posted a slowdown in half-year earnings growth amid "significant challenges" in the sector.
Nam told me she was particularly impressed that it achieved that growth without significant marketing spend.
These three are some of Africa's largest economies and their impact on overall Africa's growth is significant.
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