We provide evidence that colonic epithelium of TLR2−/− mice have altered immune responses and dysregulated proliferation under steady-state conditions and during colitis, which lead to inflammatory growth signals and predisposition to accelerated neoplastic growth.
The symptoms of such diseases include growth retardation, cancer predisposition syndromes and neurodegeneration.
Second, in addition to the role of the intrauterine environment, more recent observations have also drawn attention to the significance of infant growth in the predisposition to adult disease.
While the significance of infant growth in the predisposition to adult disease has extensive support from observational studies, it is not clear whether the detrimental adult outcomes (obesity and cardiovascular disease) are related to a specific time window.
The predisposition for normal growth is the growth potential which may be interfered with by factors indispensable for its realization; these so-called "growth circumstantials", however, are not responsible for the characteristics of growth.
NBS is an autosomal recessive chromosomal instability disorder characterised by microcephaly, stunted growth, immunodeficiency, a high cancer predisposition and a marked sensitivity towards ionising radiation [ 7].
Children with BWS have an over-growth syndrome and predispositions to develop pediatric tumors including Wilms tumor [ 49].
Perhaps the sensitive plants have a predisposition for reduced growth and less stress tolerance [ 50].
Missense mutations in CBL (Cbl proto-oncogene, E3 ubiquitin protein ligase) cause impaired growth, developmental delay, cryptorchidism and predisposition to juvenile myelomonocytic leukemia [ 8, 9].
In contrast, hypermethylation on the maternal allele in Beckwith-Wiedemann syndrome might result in increased IGF-II production and a predisposition toward tumor growth [ 8].
