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(C) Growth advantage was determined between mc2155 and mc251.
Cancer cells undergo metabolic adaptation and thereby gain selective survival and growth advantage (Fig. 1).
Despite slowing glycolysis, PKM2 provides a growth advantage to cancer cells.
A selective growth advantage imparted by an acquired mutation is at the core of cancer development.
No distinctive growth advantage was witnessed during recrystallization and grain growth of Mg-1Dy.
Moreover, the engineered strain featured a three-fold growth advantage over the wild type strain.
In addition, we provide evidence that the growth advantage is a direct result of catalytic activity.
These perturbations confer a tremendous growth advantage to the malignant cells.
It is known that not all somatic mutations confer growth advantage to the cells.
In spite of this growth advantage, dual RB/p53-deficient cells are not spontaneously transformed.
Previous studies have shown that downregulation of MME imparts a growth advantage to various cancers [26].
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