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On the basis of existing literature, a typology of four different patterns of upscaling is proposed: growing, replication, accumulation, and transformation.
We conducted a controlled experiment to determine whether a knapper's growing replication skills would be hindered if the toolstone used was switched from large flakes of an easily worked chert to nodules of less tractable one.
The growing "replication crisis" in academia refers to the inability to reproduce the findings of published papers either due to access restrictions that prevent others from being able to examine the underlying data or due to the data and methods outlined in the paper not producing the results described by the researchers.
The higher the rate of initiation and the greater the number of growing replication forks per chromosome, the higher the probability of the irreversible chromosomal collapse [ 40].
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On this basis we argue that the building of broad and deep social networks is important for growing and replication; articulating and sharing expectations is important for replication; and broad and reflexive learning processes are critical to transformation and replication.
Fig. 3 Number of duplication hops growing in the replication pattern.
The stability of prions in a growing population requires continuous replication of prions in order to keep pace with cell divisions.
The third type of fluctuation is due to periodic DNA replication in growing and dividing cells [ 3].
In vegetatively growing yeast cells, stalled replication forks activate a conserved kinase cascade including Mec1/ATR and Rad53/CHK2.
We adopted a different attenuated vaccine strategy based on an HSV-2 virus genetically deleted for the gene that encodes gD-2 (U S 6) and complemented the virus to allow a first round of replication by growing it on Vero cells encoding HSV-1 U S 6 (gD-1, VD60 cells) (Cheshenko et al., 2013).
Eight NAM founders were crossed to both B73 and Mo17, and these 16 F1 crosses (Table S1) as well as the 10 parental inbreds were grown in 20 replications of one plant per replication, scattered randomly throughout each replication.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com