A growing number of transcript profiling studies, primarily using microarrays, have compared global expression patterns among closely related species, providing insights into a range of important evolutionary questions.
Second, a growing number of transcript factors with their promoter sequences have been found, which made the potential drug targets plentiful and readily identifiable.
How this might be avoided is unclear, but despite this concern, a growing number of antisense transcripts have been shown to regulate the expression of their cognate sense transcripts through mechanisms based on RNA-RNA interaction.
To summarize, a growing number of antisense transcripts with an established function have been identified but still many questions remain concerning their mechanisms of action.
A interesting finding was that the mapped transcriptional start sites of cysR as well as of ssuR are identical with the translation start points of the encoded proteins, adding them to the growing number of leaderless transcripts of C. glutamicum.
MBNL1 sequestration disrupts the normal activity of the protein, and results in mis-splicing of a growing number of target transcripts (Osborne and Thornton, 2006; Du et al., 2010).
However, a growing number of non-coding transcripts have functional roles in gene regulation, such as siRNA [ 72] and long non-coding RNAs [ 73].
Our data combined with the growing number of reports of antisense transcripts expressed in mammals43 raises the possibility that bidirectional expression across pathogenic microsatellite expansion shown to occur in SCA8 and DM1 (ref. 41) may be common, and that possible pathogenic effects of mutations transcribed from both strands should be considered.
Non-coding RNAs (ncRNAs) are an emerging focus for both computational analysis and experimental research, resulting in a growing number of novel, non-protein coding transcripts with often unknown functions.
Among the transcripts a growing number of genes that encode active RNA species have been identified, suggesting that regulatory RNAs also need to be considered when trying to elucidate the etiology of diseases[5].
