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The two pathways were widespread at early stages, but by 40 GW they condensed and formed groups of pathways that projected to specific regions of the cortex and overlapped in some brain regions.
Further, during the Tox21 Data Challenge 2014 [27], the development of computational models which can predict the interference of these chemicals in the two groups of pathways was crowd-sourced to researchers across the globe.
Because of the shared biosynthetic enzymes in the trunk portion of each of these groups of pathways, it does not come as a surprise that a COG involved in biosynthesis of one amino acid, when used as a Psi-square query, often retrieves components of other pathways in the same group.
Groups of pathways are formed involving genetic processes, metabolic processes and signalling.
By mapping the most frequent GO terms onto the network of pathways, functional groups of pathways are clearly observed.
This result corresponded well with our previous work which identified Kinase Pathways as one of the major groups of pathways significantly enriched following MI [ 11].
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By leveraging on this pathway collection, we first searched for significant pathways in the GWAS dataset using four methods, which represent two broad groups of pathway analysis approaches.
Two groups of pathway members can be distinguished: those promoting processes required under low glucose conditions ("low glucose" group), and those promoting processes required under high glucose conditions ("high glucose" group).
Malignant tumors often share a core group of pathways that are perturbed by diverse genetic mutations.
Examination of this group of pathways in relation to histopathology findings provided a clearer understanding of PXR's role in the dramatic hepatocellular hypertrophy observed in WT mice.
The group of pathways in SKBR3 cell line associated with our protein expression data was in agreement with the group of pathways associated with gene expression data.
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