Prepolymer molecular weights were determined by gel-permeation chromatography (GPC), end-group titration, and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS); the latter also provided confirmation of end-group functionality of prepolymers.
THE determination of the degree of polymerization of polyamides or polypeptides by end-group titration is, in effect, a determination of the amount of the weakly acidic carboxyl group (dissociation constant K 2) in presence of a large excess of the base of a stronger acid, the amide or peptide group (dissociation constant K 1).
There was no significant PFS difference reported between the groups (titration: 14.5 months; placebo: 15.7 months; nonrandomized: 16.6 months).
Because of these differences in pathophysiology and the lack of guidelines for this age group, the titration of CPAP in infants is generally based on clinical parameters such as the disappearance of the stridor and retractions, the decrease in respiratory and heart rates and the normalization of gas exchange [ 2, 3].
Before each shipment, the capsules were tested to ensure potency, or lack thereof for group 2. Titration schedules were prepared on a case-to-case basis in accordance with standard practice, but dosing targets generally ranged from 1800 mg/day to 3600 mg/day three times a day.
The successful crosslinking of carbon black was demonstrated by determinations of the grafted groups via titration and via thermogravimetric analysis.
The peak pressure was significantly higher on days 3 and 5 in the decremental PEEP titration group than in the control group, and the mean pressure was significantly higher in the decremental PEEP titration group because of the higher PEEP during the first week.
Initial oxygenation improved more in the decremental PEEP titration group than in the control group.
Although the responder rate was higher in the decremental PEEP titration group than in the control group, the earlier improvement in oxygenation was not associated with increased survival rate.
The partial arterial pressure of oxygen (PaCO2) level was significantly higher in the decremental PEEP titration group than in the control group on day 1, suggesting increased dead space ventilation.
For patients in the fentanyl or morphine groups, down-titration or discontinuation of the opioid and/or hypnotic agents for neurological assessments (and subsequent up-titration afterwards) were made at the investigator's discretion and in accordance with routine practice at the investigational site.
