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Chemical synthesis has yielded amphetamine analogs with myriad functional group substitutions and diverse pharmacological properties.
Noticeably, compound 9b (2,4,6-trihydroxyl phenanthrene) with the same hydroxyl group substitutions as resveratrol, is superior to the reference compound, highlighting the importance of extension of the conjugation over multiple aromatic-rings.
We used nucleotide analog interference to identify initially 71 functional group substitutions at phosphate, 2′-ribose, and adenosine base positions that compromise RNA self-splicing in the bI5 group I intron.
On contrary, tyrosine derivatives did not form any π-π interactions and the extra volume of the electronegative group substitutions in the R1 and R2 positions which repulse the molecules to bind in the active site (Fig. 10).
Moreover, the methoxy group substitutions of compound 1 (Ginkgetin) at position 7 and 4′ significantly improved the Wnt inhibitory potency compared to compound 3, indicating that the skeleton of biflavone and the methoxy group substituted at position 7 and 4′ may be responsible for the inhibitory effect on Wnt signaling.
Both inhibitors were developed to inhibit the p110-gamma isoform of the PI3Ks and structurally, they have the same chemical backbone, but differ in side group substitutions.
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In single group substitution, a group is substituted with another group of the same norm.
Analytical data of the functionalized polymers are consistent with a quantitative functional group substitution.
Therefore, the ISC process is boosted by multiple nitrophenyl group substitution to lead TPE-4N the highest On Off contrast.
This functional group modification allowed us to explore the importance of chlorine group substitution for the cytotoxic properties.
SAR studies revealed that, electron donating group substitution on phenyl ring recommended for potent anti-leishmanial activity.
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