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Another group of miRNAs that can be used as biomarkers for sepsis belongs to the family of miRNA-4772.
This group of miRNAs, the miR-214/199 family, has five specific unique mature sequences that have been reported to regulate a variety of different targets.
Herein, we tentatively defined MSC-VEC-miRNAs as a group of miRNAs which are associated with MSC, have regulatory effects on VEC and have previously been studied in ARDS.
All but two APML patient samples clustered together showing high expression of a group of miRNAs.
This subset was drawn from the group of miRNAs that were judged to be significant.
We then calculated the average tissue specificity index value for each group of miRNAs.
Moreover, we confirmed that MVs derived from MSCs expressed a group of miRNAs specific for MSCs [24].
Our results showed that a special group of miRNAs have been expressed in the fetal liver of 27 weeks.
Furthermore, the 3'UTR may free a group of miRNAs that modulate mRNAs with related biological functions.
We expect this group of miRNAs to be regulators of housekeeping genes, which are abundant in human tissues.
Despite the similarities at the global level between the MV- and cell-derived miRNAs, we identified a group of miRNAs selectively expressed by MVs.
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