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Given the nature of the study a stringent criterion has been set for early termination of the trial on grounds of efficacy, namely p<0.001 for both the primary outcomes, else continuation of the trial being recommended.
In human epilepsy, many AEDs are used for the management of seizures but phenobarbital remains one of the most important; meta-analyses of RCTs found that only minor differences occur on the grounds of efficacy between phenobarbital and other established AEDs [ 38].
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Clinical information on the grounds of their efficacy remains limited, with most evidence derived from non-blinded non-randomized uncontrolled trials and case series [ 6].
There is consistent evidence that atomoxetine is superior to placebo while no clear differences have been found between atomoxetine and MPH on the grounds of clinical efficacy in terms of standard measures of ADHD symptom control [ 21] though there has been increasing evidence in favour of MPH [ 22].
However, it was not possible to properly analyse the full effect of ovicidal failure due to participants being withdrawn early in the study on grounds of lack of efficacy.
Randomised, placebo-controlled studies with the MMP inhibitor AG3340 in patients with non-small cell lung cancer and prostatic cancer were stopped early on grounds of lack of efficacy (Agouron, 2000).
However, in the past, such guidelines have been based on rational or practical grounds rather than evidence of efficacy, or lack thereof.
Amodiaquine is much cheaper than artesunate (currently the difference in cost is about 5 fold) so the SP+3AQ regimen has a major advantage over AS containing regimens on these grounds as well as on those of efficacy.
Collectively, these observations confirm the induction of strong allergen-specific suppressive/tolerogenic immune responses during SLIT and pave the ground for the identification of biomarkers of efficacy.
But until other international organizations start working with local collaborators in Haiti, and make efforts to appreciate economic and sociological dynamics "on the ground", the efficacy of relief work will continue to be questioned.
There is also the matter of efficacy.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com