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"groundbreaking question" is correct and usable in written English.
You can use it to refer to a question that is particularly daring, innovative, or revolutionary, typically in the context of a scientific, political, or social issue. For example, "The scientist posed a groundbreaking question to the audience: 'What kind of technology have we yet to discover?'".
Similar(60)
The unique combination of new and existing services in the Core will multiply opportunities and effectiveness in using the rich data that CEHNM members generate as well as those already available in-house or in the public domain to answer groundbreaking questions in environmental health research.
"Whether the questions are groundbreaking is not as important as how many people will be exposed to this," Mr. Bassik said.
The information in question includes the underlying data in a 1993 paper considered to be groundbreaking work on the impact of air pollution.
Answering these questions requires further molecular and clinical investigation, which will undoubtedly lead to new, perhaps groundbreaking insights for the clinical management of human glioma.
And it's groundbreaking.
His designs proved groundbreaking.
"This is groundbreaking".
It would be groundbreaking".
"This is groundbreaking research.
Back then, it was groundbreaking.
Brave, groundbreaking stuff, eh?
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com