Dr. Svoboda, 38, of Huntington, decided to build his own, developing microscopes and imaging methods to do groundbreaking research using live mice.
Along with Robert G. Denkewalter, Dr. Hirschmann headed the research team at Merck Laboratories in Rahway, N.J., that in the late 1960s designed one of two groundbreaking methods to synthesize the enzyme, ribonuclease.
Dr. Wichterle developed groundbreaking methods for producing spinal cord neurons from pluripotent embryonic stem cells in a culture dish.
Wagers, who is also principal faculty at the Harvard Stem Cell Institute and senior investigator in the section on developmental and stem cell biology at Joslin Diabetes Center, has established groundbreaking methods for manipulating stem cell genomes in situ work that opens new avenues of research and new possibilities for treating congenital and age-related diseases.
"Masterful in any genre, Ridley's groundbreaking methods and peerless directing instincts have brought to life some of the most memorable films of our time, capturing the resilience of the human spirit and captivating the hearts and minds of audiences around the world," Paris Barclay, DGA president, said in a statement.
The citation from the Royal Swedish Academy of Sciences said they won "for groundbreaking experimental methods that enable measuring and manipulation of individual quantum systems".
The Yidan Prize consists of two awards: the Yidan Prize for Education Development, awarded to Agarwal for making education more accessible to people around the world via the edX online platform, and the Yidan Prize for Education Research, awarded to Larry V. Hedges of Northwestern University for his groundbreaking statistical methods for meta-analysis.
The organization, dedicated to helping students make the best decisions about their nursing education, cited Johns Hopkins as the #1 institute in innovation for its groundbreaking teaching methods, quality of facilities, and range of master's degrees.
She is the author of the international bestseller, "Solemate: Master the Art of Aloneness & Transform Your Life", co-author of "Speaking of Success" with Jack Canfield and Stephen Covey, and the creator of the groundbreaking Illumineering Coaching method.
His then groundbreaking use of "the Method", adapted from famed Russian dramatist Constantin Stanislavski, had much to do with his movies packing an unusually powerful punch.
