Recently the groundbreaking work demonstrated that ectopic expression of defined transcription factors (Oct4, Sox2, Klf4, c-Myc, Nanog, Lin28) could reprogram murine and human somatic cells to induced pluripotent stem cells (iPSCs).
While the NPR reviewer stated that the recording "isn't groundbreaking," they praised its "coherent musical expression" and emphasis on "solid songcraft without pretense" which created a "satisfying and melodically sound album".
Last week, the tiny nation of Malta passed an internationally groundbreaking new law: the "Gender Identity, Gender Expression, and Sex Characteristics Act".
In a 2014 press release, Epic Rights lauded CBGB as a brand "synonymous with groundbreaking music, youth, adventure, rebellion and extreme expressions of individuality...the most valued symbol for rebels, misfits and music fans around the world".
This dogma was rebutted by the groundbreaking discovery of Yamanaka and colleagues that the expression of four transcription factors (TFs) could reprogram mouse and human cells into a pluripotent stage (Takahashi and Yamanaka, 2006; Takahashi et al., 2007).
The groundbreaking work by Yamanaka in 2006 demonstrated that ectopic expression of defined transcription factors could reprogram murine somatic cells to iPS cells.
In their groundbreaking paper, Perou et al. studied the patterns of gene expression in two consecutive samples of locally advanced breast cancer (Perou et al, 2000).
The authors' in vivo observations of differential transcription factor activation and gene expression as a function of fungal numbers confirm recent groundbreaking in vitro findings.
The groundbreaking findings that differentiated can be reprogrammed to iPS cells by enforced expression of a few defined factors (Oct3/4, Sox2, Klf4, and c-Myc (OSKM)) overcomes many of the technical, ethical, and political obstacles in human embryonic stem cell (ESC) research and regenerative medicine.
The rational-based method (supervised training) for development of the 80-gene molecular subtyping profile (BluePrint) is inherently different from the groundbreaking research used originally to unveil the existence of molecular subgroups using gene expression unsupervised clustering [ 2].
