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In group B, samples were grossly evaluated and the protein concentration and white blood cell count including differentiation were determined.
Efficacy was grossly evaluated in every patient 4 weeks after the start and at the completion of chemotherapy according to the Response Evaluation Criteria in Solid Tumors (RECIST) [18].
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Standard Haematoxylin & Eosin (H&E) was performed to grossly evaluate the fibrous synovial membrane, the ECM, and cell morphology.
The operated radiuses were removed on the 56th postoperative day and were grossly and histopathologically evaluated.
Segments of reconstructed airway were evaluated grossly and histologically for all animals.
Constructs were harvested after 12 weeks and evaluated grossly and microscopically by using histologic stains.
At day 7 or 14, animals were sacrificed and the lungs evaluated grossly and by histopathology.
The colons were evaluated grossly and histopathologically for aberrant crypt foci (ACF).
Therapy was given twice a week for six weeks, after which the animals were sacrificed and evaluated (grossly and histologically) for primary and metastatic tumor burden.
Each sample was evaluated grossly by three independent observers according to Wayne scoring system (available as a supplemental file) (see Supplementary Material available online at http://dx.doi.org/10.1155/2014/746138) [ 39].
At 1, 3, 6, and 9 months, the rabbits were sacrificed and their larynges were evaluated both grossly and histologically for tissue response to, and resorption characteristics of the implant, tissue cellularity, maintenance of vocal fold medialization, and airway patency.
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