The shapes of the nuclei are irregular and the ratio of nucleus to cytosol area is grossly changed.
The protein levels of MTH1 or OGG1 did neither appear to be grossly changed by MSH2 deficiency nor methotrexate exposure.
Samples for histopathology were collected from lung, trachea, stomach, intestine, oesophagus, liver, adrenal gland, kidney, testis, ovary, spleen, thymus, lymph nodes, heart, aorta, skeletal muscle, skin, feathers, brain, spinal cord and from grossly changed organs and tissues.
Grossly, degenerative changes were noted in articular cartilage of DES-exposed animals at a higher rate than those in controls.
Interestingly, WT and CD36−/− mice had equivalent levels of free fatty acids and LDL, suggesting that metabolic improvements in CD36−/− mice were not due to grossly detectable changes in circulating ligands (Supplementary material online, Table S1 ).
He called the change "grossly unfair", but ministers say it is necessary to free up housing stock and cut waste.
Presumably this re-tuning would also have to be relatively rapid, because the color-appearance of objects does not change grossly when the illuminant is changed (e.g., [ 82]); this is sometimes referred to as "discounting the illuminant".
The kidneys were without grossly visible pathological changes.
On the other hand, older children were more likely to have grossly visible and chronic changes in the duodenum, which might be because of diverse immune responses and histopathological changes between age groups (i.e., timing of CD diagnosis).
