Sentence examples for gross modifications from inspiring English sources

Malignancy was documented to be associated with gross modifications in the inherent replication-timing coordination between allelic counterparts of imprinted genes as well as of biallelically expressed loci.

Due to their regulatory role, TFs represent good targets for gross modifications of biochemical or signalling pathways for various biotechnological applications [ 45].

While the authors did not find any gross modifications of energy expenditure, they observed several intriguing hemodynamic and acid-base effects, which confirm the complex actions of this 'third gaseous mediator'.

Throughout this early postnatal period, no significant changes in cellular morphologies or gross modification of terminal projection patterns were observed; however, the presence of growth cones in even the oldest animals studied suggests that the refinement of the nigrotectal projections extends well into postnatal life.

Overall, our data suggest that invalidation of the Prnp gene does not induce gross modification of the adult mouse brain transcriptome.

These changes observed on vaginal cytology and gross modification may be an indication that GBR and its bioactives possess oestrogenic activity, and Remifemin has little or no effect on the uterine tissue as earlier reported [ 37].

During the first cleavage divisions, paternal and maternal chromosomes will become more similar as to their gross histone modification pattern (Puschendorf et al., 2008).

There are many diverse ways in which TEs can alter the genome, ranging from small sequence modifications to gross rearrangements.

Imaging analysis by electron microscopy showed that the pVII modified virions were morphologically identical to the unmodified virions (data not shown), ruling out that the pVII modification introduces any gross physical alterations of the virions as compared to their unmodified counterparts.

The slightest modification was a gross error for which he would not pardon even his closest friends, not even his fervent admirer Liszt.

Median debt payment in April for borrowers with permanent modifications was 64 percent of their gross income, up from 61 percent in March.