Sentence examples for gross defects of from inspiring English sources

In man certain gross defects in babies at birth have been shown to be associated with effects acting through the mother in early pregnancy: gross defects of eyes and ears caused by infection of the mother with rubella (German measles); and microcephalic idiocy with diagnostic use of X ray on the mother.

Moreover, the autocracy of the Khalīfah had become increasingly acceptable to most Sudanese, and, having tempered his own despotism and eliminated the gross defects of his administration, he, too, received the widespread acceptance, if not devotion, that the Sudanese had accorded the Mahdī.

Whereas CM-II and CM-III are gross defects of neuroectodermal origin, there is accumulating evidence that CM-I is a disorder of the paraaxial mesoderm that results in underdevelopment of the posterior cranial fossa (PCF) and overcrowding of the hindbrain [ 19, 25, 30].

In CGD there is a gross defect of components of the NADPH oxidase that is responsible for the respiratory burst in neutrophils.

The ALv1 lineage does not express Otd and, as expected, we do not see any gross defects in any of the otd -/- ALv1 clones we have recovered (see Author response image 1).

These results lead us to conclude that the aberrant accumulation of GLR-1 in uev-1 mutants is not because of gross defects in synaptic protein trafficking or in the formation of synapses to GLR-1-expressing neurons.

Although gross defects in the organisation of the cortical F-actin were not observed in any of the validated hits upon visualisation with phalloidin, it is possible that these depletions may have disrupted metabolic processes or the structure of organelles, such as the ER, and this affected indirectly the organisation of actin cytoskeleton around the tER-Golgi units.

His attempts to galvanize the war effort and remedy gross defects in many branches of the services were partly nullified by bad appointments at home and in Crimea.

Ultra-structural analysis revealed gross defects in the cuticles of these worms.

These data suggest gross defects leading to mislocalization of the major chaperone together with additional effects manifest throughout the cell.

Despite absence of gross defects during development, FHL2-deficient mice harbor cardiac hypertrophy in response to β-adrenergic stimulation, osteopenia due to decreased activity of osteoblasts and wound healing defect [15], [18], [19].