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At a higher BZ-POSS content, gross aggregation occurs and results in a lower than expected improvement in the thermal properties.
Similarly, we saw no correlation between [PSI+] phenotype and fluorescence pattern of our Sup35-GFP fusion protein, suggesting effects on prion phenotype were not related to specific changes in gross aggregation state of Sup35p.
The fact that complete backbone assignments were obtained indicates that the P23T substitution did not cause global unfolding and/or gross aggregation.
In contrast, Poly-3 led to gross aggregation and clear membrane damage inferred from the dramatic increase in red fluorescence intensity, while under the green filter the cells now appeared more yellow compared to the Poly-1 or PGON trials (compare Figure 3C to 3A and 3E).
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This accurate bottom level accounting guards against gross errors of aggregation, without, of course, preventing the model user from producing and presenting results at a much less detailed level.
Mice overexpressing the G2019S mutation in LRRK2 do not reproduce any obvious gross neuropathological phenotypes nor is α-syn aggregation observed, although this LRRK2 mutation may accelerate the pathogenic phenotype of A53T α-syn mice [ 136- 138].
Recently, in a group of 400 healthy volunteers, Grosser et al. [ 54] have assessed platelet aggregation and serum TXB2 concentration after ingestion of a single oral dose of enteric-coated versus immediate-release ASA.
Canopy interception was correlated with gross precipitation, LAI, canopy density, biomass, mixed degree, uniform angle index, aggregation index.
No gross differences are found either in attachment rates to plastic and ECM or in aggregation and disaggregation rates.
For loss aggregation across counties to the provincial level or group of counties, we assumed that the county gross loss follows a Beta distribution (frequently used in catastrophe risk modeling).
Aggregation and opinion are cheap.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com