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Homozygous hyh mice demonstrated decreased expression of αSNAP protein in the intestinal epithelium, but did not display gross abnormalities of epithelial architecture in the colon and ileum.
MRI was obtained and demonstrated gross abnormalities of T5-T6 and multiple epidural abscesses in the T5-T6 region, causing displacement of the spinal cord posteriorly (Fig. 1).
We never observed any gross abnormalities of the retinas in vertical sections (Figure S1 & S2).
Again, 3D and 2D reconstructions did not unveil gross abnormalities of lumbar spine morphology (Figure 4A), but trabecular bone analyses revealed a significantly reduced bone volume per total volume (BV/TV, 18.9 +/− 1.5% vs 15.7 +/− 2.5%) in Lrp4 ECD mutants as compared to wild type littermates, accompanied by the according changes in trabecular separation and trabecular number (Figure 4B).
Gross abnormalities of KO mouse bones were not observed as shown in the X-ray of bone from both FL and KO mice (Figure 7), suggesting that even OGR1 might even have a role in osteoclastogenesis, the overall effects are not apparent and that a redundant role of other genes may be involved in vivo.
Necropsy did not reveal any gross abnormalities of any organs.
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No gross abnormality of NK or platelet function was observed.
Since we only select those compounds that retard embryonic growth but not induce gross abnormality of embryonic body and tissues, they may have less toxicity in further preclinical studies.
Postmortem examination did not reveal any gross abnormality of the brain and the organs of the chest and abdominal cavities in all treated groups.
Thus it is unlikely that the glucose intolerance and defective insulin secretion of Panc- Bmal1 −/− mice reflects a gross abnormality of islet development.
They had no history of neurologic disorders or psychiatric illnesses and no gross abnormalities on brain MR examinations.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com