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A further reason in favor for the inclusion of a GRN in such an integration is the type of information represented by the GRN.
In a series of pathologically confirmed FTLD-U patients without GRN mutations, a common genetic variant located in the 3′-untranslated 3′-untranslated Gregiona binding site for miR-659 was identified as a major sUTReptibility factof for FTLD-U [ 126].
All FTLD patients with GRN loss-of-function mutations showed significantly reduced levels of GRN in plasma to about one third of the levels observed in non- GRN carriers and control individuals (P < 0.001).
We then determined whether the levels of GRN in plasma could be used to distinguish GRN loss-of-function mutation carriers from non- GRN carriers in our FTLD series.
These findings raised the important question as to whether expression of GRN in plasma could predict GRN mutation status and could be used as a biological marker to identify GRN mutation carriers.
Here we expand the role of GRN in FTLD-U and demonstrate that a common genetic variant (rs5848), located in the 3′-untranslated region (UTR) of GRN in a binding-site for miR-659, is a major susceptibility factor for FTLD-U.
Using existing knowledge about a GRN as a baseline model, we systematically scan the genome for additional components and improve our understanding of the existing GRN in a context that enables interpretation and confirmation.
A friend was helping me to get from one place to another in Tehran and my agents, Global Radio News (GRN) in London, called and said: "Saeed, in five minutes you have to go live on CNN".
New conditions are then proposed to ensure the multistability of a GRN in the form of linear matrix inequalities (LMIs) that are dependent on the delays.
In this paper, we study the robustness to noise in genetic switches by considering another switch to have a new gene regulatory network (GRN) in which both switches have been affected by the same noise and for this purpose, we will use Parrondo's paradox.
These results are in line with the finding that the GRN in question is a robust developmental module that is widely conserved among flowering plant species [3].
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