Finally, there's the grim possibility that the small hits matter as much as the big ones -- a hypothesis for which there is growing evidence.
The detection of GRIM-19 mutations in four of 26 apparently sporadic Hürthle cell tumours, and their absence in 20 non-Hürthle cell tumours and 96 blood donors support the hypothesis that alterations of GRIM-19 are involved in the etiopathogenesis of these tumours.
Grim and others utilize the idea of qualitative hypothesis testing in focus group interviews in order to test a generated hypothesis [12].
In line with this hypothesis, P2X7R is over-expressed in several human malignancies including NB, a pediatric tumor with grim prognosis in its metastatic presentation at diagnosis.
On the basis of our hypothesis, we took this optimal cut-off for walking speed to be the best estimation of the Grim Reaper's pace.
I know it sounds grim, but remember that until the US Airways-American Airlines deal is finalized, everything I mentioned in this article is testimony, speculation and hypothesis on what might happen.
Thus, both European and New Zealand populations are equally suitable for tests of the egg arrangement hypothesis with no difference being predicted for populations sympatric or allopatric with any interspecific brood parasites (see also Grim et al. 2011).
Despite sample sizes that are comparable or larger than those in experimental manipulations in most egg rejection studies (Grim 2007; own unpublished review of sample sizes in brood parasitism studies), we found no experimental support for the egg arrangement hypothesis.
