As the episode ends, the castle gate goes up, the snow swirls, and our fur-clad men without hats, looking grim, head off into the mystic.
In Drosophila, apoptotic inputs converge to a common death program through the activation of the proapoptotic genes: reaper (rpr), grim, head involution defective (hid) and sickle (skl).
All was looking so grim heading into Sunday's Game 4 against the Pacers, what with the injury to Chris Bosh and an astoundingly inept performance in Game 3.
TheCapeCrusaider Martina Franca's outskirts may look grim but head to the Centro Storico (old town) and you'll find a delightful and fairly tourist-free, by contrast with Lecce, baroque centre that's lively of a summer evening.
Archibald the Grim became head of the main line, known as the "Black Douglases".
To pre-order Panda Bear Meets the Grim Reaper, head over to Domino Records.
Ectopic JNK activity in WT tissue leads to apoptosis (Igaki et al., 2002), so we co-expressed the JNK-activating ligand Eiger with a microRNA targeting the pro-apoptotic genes reaper, grim, and head involution defective (miRGH) to block both cell death and caspase activation (Siegrist et al., 2010).
To investigate this possibility, we performed a MARCM clonal analysis of neuroblast lineages in the general region of the developing tritocerebral region using H99, a deficiency removing the proapoptotic genes reaper, grim and head involution defective, in an otherwise wildtype background (White et al., 1994).
First they are orphaned; now they leave the family home with all its grim associations and head off on their dangerous adventure, drawn into the seductive, hallucinatory darkness of Stockholm.
However, any notion this was merely a sympathetic gesture of support for a beaten and drained captain were dispelled quickly enough as Robinson took charge of the proceedings while Edwards sat in silence, head down, looking grim.
looked grim and shook his head.
