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PD are calculated for each grid compartment or macrophage using local antibiotic concentrations.
Bacterial populations are captured by continuous variables representing extracellular replicating Mtb (in each 'healthy' grid compartment), extracellular non-replicating Mtb (in each caseated grid compartment) and intracellular Mtb (in each macrophage).
When the cumulative number of host cell deaths in a grid compartment reaches a threshold the compartment becomes caseated.
11 Cellular accumulation of soluble antibiotics is assumed at pseudo-steady-state given by: Eq 10 Eq 11 C Ext and C Int are extra- and intracellular concentrations (mg/ml), and L Grid is volume (ml) of a grid compartment.
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Macrophages burst when intracellular Mtb reach the carrying capacity of a macrophage, distributing the bacteria to surrounding grid compartments.
In Byzantine murals and in Indian and medieval manuscript paintings, narrative sequences were depicted in grid patterns, each "compartment" of the design representing a visual chapter in a religious story or a mythological or historical epic.
If no particular phase relationship between the grids in each compartment existed, the local and global models would on average fall in the middle of the distribution of the randomly offset grids.
We assessed whether in the first and last five sessions the local or global models fitted the data significantly better than would be expected under the null hypothesis of no particular phase relationship between the grids in each compartment.
The compartments have different color walls (black vs white) and distinct floor textures (fine grid in the black compartment and wide grid in the white one).
Both metal grid floors of the compartments are weight sensitive and electrifiable.
In contrast, ideal grids fitted in the global model consisted of a single grid pattern spanning both compartments.
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