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LandScan estimates were generated by an algorithm that allocates census figures to one square kilometer grid cells based on land surface characteristics identified by satellite images.
Rather, it assigns a continuity value to grid cells based on their distance from different types of built areas that are weighted according to their estimated impact.
The choice of the scoring methodology does not have a strong impact on the ranking of the grid cells based on the hotspots methodology (Online resource 1).
Knowing the class of each of the grid cells based on the marked epithelial regions, K-means clustering was again used to divide the space of the three base colors into three clusters representing the epithelial, stromal and luminal regions.
Land-use Intensity Index (VA,VPINTENSITY): represents changes in land use intensity and scores grid cells based on the relative proportions of five land use classes output from the IAP in order of increasing intensity: abandoned land < forestry < extensive agriculture < intensive agriculture < urban.
Case locations were geocoded (assigned to specific grid cells) based on the location of the village or the centroid of the sublocation, location, or division in which the village was located if the location of the village could not be located.
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These are labelled by numbers (Grid cell) based on the land use [33] and the ecological land classes [34].
The D8 algorithm (O'Callaghan and Mark 1984) was used to determine flow direction of a grid cell based on elevations in a 3 × 3 window around it.
The maximum storage capacity of the root zone (Srzmax) is assigned to each grid cell based on the soil properties and the root depths according to the land cover maps (Hapuarachchi et al. 2004b).
Then, they divided the country into squares the size of an average county, about 2500 square kilometers, and determined which plants were present in each grid cell based on distribution data from the Global Biodiversity Information Facility, an international organization that provides open-access biodiversity data.
Metrics of water supply and landscape stress are developed using a California-wide grid-based water balance model, the Basin Characterization Model (BCM; Flint et al. 2013; Flint and Flint 2014) that calculates the monthly or daily water balance for each 270-m grid cell based on a rigorous energy balance and soil moisture depletion calculation.
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