The main difference between SQPV positive red squirrel tissues and positive grey squirrel tissue is that grey squirrel samples contain considerably less viral DNA than the corresponding red squirrel samples (by several orders of magnitude).
The results replicate known findings in the brain-imaging field, with the improvement that our analyses are restricted to grey matter tissue.
Grey matter tissue was stained with monoclonal antibodies against PLP, NeuN and MAP2 using immunohistochemical detection.
Summing the ten individual grey matter tissue classes and thresholding at 50%% created a binarized grey matter mask.
We anticipated that the complementary character of both voxel-based techniques would allow more straightforward interpretation between cortical folding abnormalities and grey matter tissue loss.
Adolescence is a critical time for neurodevelopment and multiple studies have reported intense reductions of grey matter tissue in the pubescent period.
In many clinical populations, particularly AD, the degree of atrophy is high, impacting ventricle size and total intracranial volume and resulting in the potential misattribution of WMH to the grey matter tissue compartment [ 12].
The percentage of overlap of white and grey matter tissue with the statistical lesion maps for repetition and comprehension, respectively, was determined by using MRIcron software (Rorden et al., 2007).
The ADC is often displayed on pixel-by-pixel maps (ADC maps), which are automatically generated from the commercial workstations of the MRI scanners and commonly displayed in grey scale: tissues with higher ADC values (increased diffusion) appear bright and tissues with lower ADC values (impeded diffusion) appear dark.
Thus, the rCBF measures are a heterogeneous mixture derived from both the white and grey matter tissues, vascular volumes, and cerebrospinal fluid spaces, but the relative weights of the individual tissue components are unknown [21, 22, 24 26].
