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As shown in Fig. 10D, genes encoding transmembrane proteins were expressed in human CV taste bud cells with no detectable or greatly reduced expression in lingual epithelium.
Here, co-expression of Nrf2 greatly reduced expression of STING (Supplementary Fig. 5a).
As can be seen in Figure 2b, the latter mutation greatly reduced expression of the VP2fluc product, supporting the idea that an interaction between the 18S rRNA and the mRNA just upstream of the termination-reinitiation site is required.
Several studies show greatly reduced expression of CLU in tumors compared with normal tissue, including testicular tumor, von Hippel-Lindau (pVHL -defective renal tumor, esopVHL -defectives cell carenalma[30]–[34].
This difference between CD4 and CD8 is consistent with the greatly reduced expression of MHC II on TECs, while MHC I was almost normal in the Foxn1Δ/Δ thymus [10], (Fig. 5).
Immunohistochemical analysis in primary cancer tissue confirmed the absence or greatly reduced expression of FHIT protein levels in tumor cells, in contrast to high levels of expression in the adjacent normal prostate epithelium [12], [13].
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Analysis of gonad development in XY byg/byg embryos revealed failure to execute the testis-determining programme due to delayed and greatly reduced levels of Sry expression.
This seems unlikely given the high degree of Cre recombinase activity that we observed in all tissues examined as well as the greatly reduced level of polycystin expression that was present in endothelial cells isolated from Tie2-Cre+ specimens.
Close inspection of the OPC in these experiments revealed that DPN expression was greatly reduced or abolished in most NBs and their progeny where PROS expression was induced at high level (Fig. 6E,F',F).
Animal models in which MSTN expression is greatly reduced exhibit gross muscle hypertrophy [ 31].
Transfection of highly immunogenic tumors such as mouse colon carcinoma (colon 26) with IL-27 expression vector greatly reduced tumor growth, which was mainly mediated by CD8+ T cells.
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