Sentence examples for greatly reduced activity from inspiring English sources
Taken together, these experiments suggest that regulatory regions that are normally resident on the autosomes and actively drive expression in the testes, have greatly reduced activity in this tissue when they are relocated to the X chromosome.
Cell-based antiviral activity assays utilizing different variants of mGRFT indicated that the monomeric form of the lectin had greatly reduced activity against HIV-1, suggesting that the antiviral activity of GRFT stems from crosslinking and aggregation of viral particles via multivalent interactions between GRFT and oligosaccharides present on HIV envelope glycoproteins.
The primary symptoms of Parkinson's disease result from greatly reduced activity of dopamine-secreting cells caused by cell death in the pars compacta region of the substantia nigra.
Additionally, age was found to have a significant effect on Notch1 γ-secretase activity with both male and female mice having greatly reduced activity in aged brain suggesting altered substrate processing abilities with age.
The ATM protein immunoprecipitated from A-T213 LCL lysate showed greatly reduced activity towards a p53 substrate after DNA damage (∼12% of normal).
Its greatly reduced activity suggests that Arg72, which is located in the vicinity of the scissile phosphate, has a more important role in aligning the substrate for cleavage than enhancing substrate affinity.
The single and double mutants of Lys158 have greatly reduced activities ranging from 14- to 1000-fold.
Synthetic peptides with 1, 3 or 4 extra AAs flanking the N-terminus of the CLV3p12 showed greatly reduced activities in terminating RMs in vitro, while a peptide with 5 extra AAs restored the activity completely.
A master grid map showed that large steric groups at the R2 position, the nitrogen of the amide bond and position Y could greatly reduce activity, and the presence of large steric groups placed at positions X, R4 and surrounding the oxygen atom of the amide bond, may increase the activity of thiazolides against Neospora caninum tachyzoites.
Changing the monodentate ligand from chloride to pyridine (py) in Ru arene complexes blocks hydrolysis, and can greatly reduce activity toward cancer cells.
Deletion of the ATF1 binding site in the somatostatin promoter (Δ(−42 SomCAT) greatly reduces activity, strongly suggesting that endogenous EWS/ATF1 in CCS cells is responsible for high somatostatin promoter under the above conditions (Brown et al, 1995).
