The greatest transcript level regulation was observed for Kiss1 (Tables 1, 4), measured in GKO mice which showed strong hormonal regulation (approximately 12 fold down-regulated with T) and moderate genotype dependence (approximately 2 fold up-regulated in the GKO animals).
Using PCLS, we were able to ascertain that the resident cells within the smoke-exposed lung were producing greater transcript levels of inflammatory chemokines in response to a dsRNA stimulus and to an influenza virus infection ex vivo.
The putative DSM 1313 malic enzyme gene (Clo1313_1878) showed slightly greater transcript levels after methyl viologen treatment, but not at levels considered significant (Additional file 2).
In contrast, tenascin-C (TNC), which is typically found in provisional matrices throughout development and wound healing [ 49- 52], demonstrated greater transcript levels in repair tissue by microarray analyses.
Consistently, X-up genes show greater transcript levels than all X-linked genes in wild type, because the latter category includes genes not expressed in the germline.
Greater transcript levels were detected after the addition of 1 mM GSH, 1 mM ASA and PEG in Ch and after treatment with 0.5 and 1 mM GSSG in Tsp compared with the other genotype.
Correlation analysis showed that the greater transcript level of ZCCT2 was also associated with a higher expression of CBF14 and its target genes in Ch compared to Tsp (Additional file 6).
The greatest increases in transcript levels in cells growing with the electrode as the electron acceptor were in the gene for the structural subunit of pilin, pilA and for GSU1497, which is adjacent to pilA and is annotated as a conserved hypothetical protein (Table 2).
Among the genes with the greatest increase in transcript levels during wakefulness are a set that could mediate elongation of astrocytic processes, including Trio, Synj2, and Gem.
This set included the gene with the greatest increase in transcript levels during growth on benzoate, a 50-fold induced thiolase (Gmet_2074) (Table 2).
