However, there might be trade-offs in terms of greater structural and compositional changes at LRBA compared with HRBA.
The current state-of-the-art in catalyst design allows the preparation of carbohydrate-containing molecules with great structural and functional diversity.
These results provide new information about the modular architecture and domain dynamics of helicases, and suggest, by comparison with the hexameric bacteriophage T7 gp4 and SV40 large T-antigen helicases, that a great structural and mechanistic diversity may exist among the hexameric helicases.
In this respect, as second-generation biosimilars are endowed with much greater structural and molecular complexity, which might translate into a number of pharmacological and therapeutic issues, they raise new challenges for manufacturers and regulatory authorities as well as new concerns for clinicians.
The Ins2 gene has greater structural and functional similarity to other mammalian insulin genes, whereas Ins1 is considered to be a functional retroposon since it possesses only one of the two introns present in Ins2 and other mammalian insulin genes [1].
The combination of DM and hypertension induces greater structural and functional cardiac damage than either condition alone [ 9].
The Ontario and Dutch healthcare systems, characterized mainly as Beveridge and Bismarckian systems, respectively, are undergoing great structural and regulatory changes.
The hub vulnerability hypothesis would predict that an acute severe global insult would cause greater structural and functional damage to hub regions than to non-hubs.
Finally real proteins with great structural and chemical diversity would emerge, many of which would act as independent functional molecules, taking the role of most functional RNAs.
A more confident prediction would likely require greater structural and kinetic details of pertinent signaling pathways leading from exposure to LPS and TCDD up to the bistable circuit, and perhaps a more complete description of the bistable circuit itself.
