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According to a 2005 review, due to the high levels of mortality and morbidity caused by malaria especially the P. falciparum species it has placed the greatest selective pressure on the human genome in recent history.
Several environmental parameters show a degree of correlation, complicating attempts to identify the variable that may exert greatest selective pressure.
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Moreover Z –test of selection suggested both ABS and PSS were under great selective pressure.
Evidently this region, near to the SST, may have found a greater selective pressure than the rest of the promoter during selection for better environmental traits under higher radiation levels found at high altitudes or even during domestication to obtain greater yield.
Thus, according to the selection for energy cost hypothesis, highly expressed genes are likely to experience greater selective pressure for a reduction in transcript length [1].
We expected that reverse polymerizing organisms, with the increased penalty for a spontaneous hydrolysis event, would have a greater selective pressure to evolve a faster polymerase holding all else constant.
However, those phages that are lytic will be under greater selective pressure than plasmids.
In other words, S/C may be under relatively greater selective pressure in some genes than Fop and vice-versa.
Thus, the great virulence that characterized the first outbreaks of RHD would have caused a strong immune response in the rabbit, generating great selective pressure.
The frequency of SFPs among the genomic features shows greater selective pressure on functional regions of the genome especially in coding areas, rRNA and tRNA.
HSP85 is an example of an extremely conserved gene with virtually no differences between repeat copies, indicating that there is great selective pressure to keep this gene intact.
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