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The phrase 'greatest sadness' is correct and usable in written English.
You can use it to express the idea of extreme sorrow or unhappiness. For example, you might write: "The news of her daughter's death filled her with her greatest sadness."
Exact(22)
My greatest sadness is that he will never forget.
Her greatest sadness was her daughter's death from cancer in 2002.
With the greatest sadness, we mourn the passing of Henry Moskowitz.
Scotland's first minister, Alex Salmond, said he had learned of the cardinal's decision with "the greatest sadness".
It is with the greatest sadness that we report that Erica passed away on May 1, 2016, after a brief, but a brave, battle with cancer.
The greatest sadness in my life — other than my marriage, to Linda, which didn't work — is that I have been forced to work outside the academic mainstream...."....
Similar(38)
Great sadness.
There's a great sadness.
We are left with great sadness".
I felt a great sadness.
"I feel a great sadness," he said.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com