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That's essentially the greatest issue that faced astronauts who volunteered for a 17-month space simulation called the Mars500 project.
I think the greatest issue that youth face today is that they are told to wait until they are older, that they're too young, too idealistic, that they need to leave the big issues to the adults.
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A second great issue that confronted Burke in 1765 was the quarrel with the American colonies.
There is a visceral fascination with leaders and their character, and with the great issue that surrounds them: can they be made or are they only ever born?There is no general agreement about the qualities of a leader.
Looking forward, our 2017 grantees will continue to challenge the status quo and take on some of the greatest issues that we face as a society today.
There is already the great issue that almost half of the eligible voters did not vote.
It's a great issue that I just can't do justice in this blog.
At the conceptual level, a greater issue that constitutes a potentially important limitation is linked to the historical challenge of defining mental health and the ways in which mental health manifests in minority cultures.
It barely mentioned the great issues that came to define her as a Prime Minister, such as curbing the unions, cutting public services, privatisation, or reducing income tax.
The Western world still has prickly problems to confront: The progressive disappearance of the great issues that used to fire our minds has resulted in a narrow intellectual life — just as the possibility of reaching new horizons has considerably increased thanks to modern means of communication.
"I don't see the benefit of us losing our soul over two great issues that are the problems of our time," said another Democratic congresswoman shortly after the caucus briefly united to vote unanimously against a procedural motion in the run-up to the main vote.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com