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The phrase "greatest interest" is correct and commonly used in written English.
It can be used to refer to something that is of the most importance or significance in a particular situation. Example: "The greatest interest of the company is to increase profits for its shareholders."
Exact(59)
But his greatest interest outside physics was in plants.
At all times his family was his greatest interest.
"My greatest interest is being involved with young people".
But the section that will attract greatest interest is disappointing.
The greatest interest and the greatest entertainment, is in working.
"And that may not be where the coffee company's greatest interest has been.
His greatest interest, at the end, was in biology and neurology.
His greatest interest was astronomy, and he built an observatory (begun in 1428) at Samarkand.
Some of the paper's greatest interest arises when Doris hollers back.
(Of greatest interest of all are handwritten letters; cross-outs illuminate the writer's mind).
The latter, no doubt, will be of greatest interest to I.B.M.'s paying clients.
Related(20)
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com