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For fibroblasts from subjects with HGPS with and without FTI treatment, we selected genes that showed the greatest fold changes in expression.
The genes with the greatest fold changes in the datasets, FOXC1 and VAX1, will require future validation in a larger series of prostate tumours.
Lipocalin 2, αM integrin and CD8a exhibited the greatest fold changes in gene expression.
Table S3 lists the 100 genes with the greatest fold changes (ranging from 401 to 38).
The names of the genes that showed the greatest fold changes and those genes had the greatest fold changes due to RXRα deficiency at 6-month old age are listed (tables 9 and 10).
Details for the ten miRNA* with the greatest fold changes in RA are given in Table 1 further information can be found in Additional file 6 Tables S1 and S4.
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Interestingly the greatest fold change was seen in men.
The greatest fold change associated with the VAX102 vaccine was seen in the men.
A partial list of these transcripts ranked according to greatest fold change in expression is shown in Table 1.
Scn7a showed the greatest fold change, with more than ten fold elevated expression in GEC compared to both cortex (with glomeruli removed) and medullary endothelial cells.
The gene with the greatest fold change increase in expression both before and following vaccination was MIG, followed by IFN-γ then FoxP3 (Table 1).
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