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The greatest downside of industrialization is not exploitation of workers but toxic air and water.
For the Nets, the greatest downside of losing four straight games is losing the momentum and credibility built during a spectacular regular season.
From current levels, we see the greatest downside to iron ore; we expect copper to hover around the top end of the cost curve (220c) until the market moves back into deficit (2018+) and we anticipate only a shallow recovery in the other base metals.
"The greatest downside of refusing to hand US service members over to Philippine authorities is that it creates the perception, justified or not, that no US soldier will actually serve time for a crime due to political pressure from Washington," Poling said.
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The potential risk to privacy is one of the greatest downsides of big data.
"I believe that the risks to the inflation outlook have become more balanced," he said, "given the greater downside risks to real growth".
The benefits of prostate cancer screening, he said, are "modest at best and with a greater downside than any other cancer we screen for".
The great downside of the revolutionary and progressive impact of warfare is the attempt by the state to make the citizen into state property.
There is little upside – and great downside – for a politician who can be plausibly cast as "weak" or a comfort to the enemy.
But John Walsh, acting head of the Office of the Comptroller of the Currency, who sits on the F.D.I.C. board and was the lone opposition vote, testified that the deadline could have been extended, and that "we didn't see any great downside" to doing so.
"Uncertainty and challenges characterize 2008, with greater downside risk than real estate markets have faced in close to two decades," concluded the Emerging Trends in Real Estate report by PricewaterhouseCoopers and the Urban Land Institute, which interviewed more than 600 developers, services firms and investors over the summer.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com