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The trajectory analysis reveals that the N-terminal domain (EIN) and the P-His domain residues exhibited the greatest conformational changes while the active site shows minimum residual fluctuations and is considered as the most stable domain.
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Similar observations and rationale were described for proteins on the hydrophilic and positively charged –NH2 surfaces, resulting in greater conformational changes [ 292].
Necessarily, the proteasome undergoes large conformational changes during its operation.
No large conformational changes upon complex formation.
Each induced large conformational changes in the cellular keratin.
(10) Small binding events can often cause large conformational changes.
These systems exhibit large conformational changes during their functional cycles.
Large conformational changes are induced upon DNA binding.
Moreover, TRPML1 exhibits great conformational change in the filter region when compared with TRPP2-SI (Fig. 3E).
Reduced competition for interfacial space at lower protein concentrations is believed to result in greater conformational change and hence entanglement on adsorption to the clean interface.
Particularly, during the process of complex formation at the air/water interface, great conformational change of the alkyl chain was observed for HNOA-2 in comparison with that of other compounds.
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