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"greatest burden" is correct and usable in written English.
You can use it to refer to something that is very difficult to bear. For example, "The greatest burden for a single mom is the stress of balancing work and home life."
Exact(60)
The mortality component was responsible for the greatest burden.
Administration officials acknowledge that Mr. Arafat bore the greatest burden.
The greatest burden falls on those with modest savings.
Debt, at about £306m, remains Johnston Press's greatest burden.
The greatest burden is on the Bank of Japan.
Negative symptoms account for the greatest burden of illness among individuals with schizophrenia.
Their greatest burden is two September collapses, in 2007 and 2008.
"Overhead is the greatest burden a publisher has," Mr. Wieder said.
Vertical equity means those who have the greatest capacity to pay taxes bear the greatest burden.
Paddick, as a Lib Dem, says those with the broadest shoulders should take the greatest burden.
"Those with the broadest shoulders will bear the greatest burden," he says.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com