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Our greater understanding of basic physiologic principles has already had a major impact on the treatment of critically ill patients.
Therefore, it is only through a greater understanding of basic scientific concepts that researchers will become able to identify the few questions that are most likely to be of clinical benefit and that should be systematically tested in large, high quality epidemiological studies with sufficient power to demonstrate clinically significant differences.
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Both forward and reverse genetic approaches will benefit genetic control programs both directly, through the development of novel strains carrying beneficial traits, and indirectly, through the development of a greater understanding of the basic biology of mosquitoes.
We believe there is a need for in vitro studies designed to distinguish between brain α-Klotho and other pools of α-Klotho, and for a greater understanding of the basic function of soluble α-Klotho.
The initiative generated some skepticism among scientists who said that beating cancer was far more complicated than putting a man on the moon, and required vast increases in funding and a much greater understanding of the basic biology of the disease.
This activity has provided a greater understanding of the basic biology of the target, answering many questions about the potential therapeutic roles for histamine H3 receptor ligands and also raising some more fundamental questions about the nature of the receptor system.
We encourage neurologists and course organisers to work towards greater understanding of neuroanatomy and basic neuroscience through integration of pre-clinical and clinical neurology teaching, for example by increasing case-based/bedside teaching and ensuring teaching remains relevant and focused on the most important principles.
In the longer term it may present new targets for drug treatment and better diagnosis, and a greater understanding of the mechanisms and basic biology of prostate cancer.
Nevertheless, a need for greater understanding of this disease, including basic questions with regard to diagnosis and treatment, remains.
GPCR pharmacology has benefited enormously from the application of fluorescence-based technologies and we now possess a much greater understanding of this receptor family's basic molecular mechanisms of action through the careful design and judicious use of fluorescent peptide and small-molecule-based ligands.
We now have the ability to reveal brain function on a number of different levels from insights into function to mechanisms of behavior to providing a greater understanding of the cells that comprise the basic fundamental units of the brain and the computations they perform.
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