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After oral administration in rats, skin concentrations of pimecrolimus were consistently greater (twofold) than that of tacrolimus whereas in other tissues tested (blood, lymph nodes), concentrations of tacrolimus were greater (6-fold and 50-fold, respectively) [ 111].
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Differential expression for listed genes was either greater than twofold overexpression or less than twofold downregulation (negative values).
Moreover, there was a greater than twofold decrease in the number of irradiated NSPs in S phase, which was paralleled by a greater than twofold increase in the number of NSPs in G2/M phase.
Peaks were called when enriched greater than twofold over input and greater than fourfold over local tag counts, with FDR 0.001 (Benjamin-Hochberg).
There is a greater than twofold enrichment of enzymes in the current target set29 compared to the Census proteins (Census proteins: 25%; drug targets (all therapeutic areas): 55%; drug targets (oncology): 64%).
Protein spots representing greater than twofold alteration in expression were picked using an Ettan Spot Picker (GE Healthcare Biosciences).
This marks a rapid (greater than twofold) increase over the 17-year period from 1992 to 2008, which is an important finding.
Patients homozygous for the APOE ε3 isoform had a greater than twofold increased odds of F2-F4 fibrosis (p = 1.8 × 10 -5)), independent of serum lipid and lipoprotein levels.
Lefaivre et al. showed that this increase in major complications is greater than twofold if the delay exceeds 48 h [12].
The average adhesion area of cells was calculated using ImageJ, and a greater than twofold difference was observed between the TCP and the PNS (Figure 4, bottom graph).
There was a greater than twofold difference in prevalence between blacks (8.4%) and whites (3.8%) (P < 0.001); monoclonal gammopathy prevalence increased with age, and was greater in men than women.
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