X-ray crystallography data were also consistent with the NMR observation, in which most of the changes in chemical shift took place in the residues close to C122, and this area was likely to undergo greater structural change than in the C164 residue area (Fig. 3B).
However, α-syn appears to induce a greater structural change in Aβ42.
The most significant change is probably the proline-to-leucine amino acid change leading to a greater structural change and the function of the protein.
The unique Tm transition above 80 °C was shown to be a rate-dependent process with a shifted melting transition and greater structural change observed under slower thermal stress conditions.
We have also observed in polyproline helices, which lack both secondary structure interactions with hydrogen bond donors and an appreciable helix dipole, that the dianionic phosphorylated residues induce a greater structural change than monoanionic phosphates, both by CD and by NMR.
At the end of the Mesozoic, the region of the Karakorams was characterized by great structural changes, and the Karakorams emerged as the result of intensive geologically recent upheavals.
Urban females have experienced the greatest structural changes in disease patterns and mortality transition compared to other population categories and are leading in epidemiological transition.
He is also making big structural changes.
The NHS is already undergoing arguably the greatest structural change of any public sector organisation: figures from the Royal College of Nursing show 56,000 posts have been lost across the UK since 2010.
