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These calculations confirmed that oscillations are present for a much greater range of parameter values under Parkinsonian conditions (Fig. 13), and similarly that the minimum value of α required for oscillations was always much higher in the healthy case than in the Parkinsonian one (0.8 vs. 0.65, not shown).
In contrast, a broad, shallow trough implies that a greater range of parameter values can describe the data for this model (i.e., uncertain/imprecise parameter estimates).
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The Mercedes steering wheel has more, and a greater range of adjustments, on all sorts of parameters than on many other cars; Hamilton's predecessor Michael Schumacher fine-tuned the set-up every lap, and would have had more buttons and switches if possible, always looking for that infinitesimal improvement.
Circadian modelling includes a 24-h period and for these models additional harmonic terms would need to provide an appropriate fit, increasing the number of parameters estimated and demanding a greater range of data.
We expect equal functional scores, greater range of motion, less dislocations, fewer periprosthetic radiolucencies and increased prosthetic survival with the MM articulation (secondary outcome parameters).
Second, as is often the case with large networks, persistence of observed phenomena is robust to a large range of most parameter values and therefore identifying these parameters exactly is not of great interest.
To test a great range of possible scenarios, we varied two parameters to come up with different sets of test instances.
And a great range of T-shirts.
Higher-order multimerization can exhibit greater noise suppression capabilities, but only for a more limited range of parameter values that lead to properly balanced numbers of the multimers in the various forms.
This is equivalent to putting a hard bound on possible range of parameter estimates.
We sampled 5000 sets of parameter values for the steady-state analysis over a wide range of parameter values (Supplementary Fig. S1).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com