However, since residual pollution remains in the aquifer, some greater level of optimisation is required to optimise placement of bores and adjust pumping and re-inject rates to achieve more effective capture and removal of the contamination and hence significantly improve the clean-up.
An important parallel is developed with the field of structural reliability analysis (i.e., probabilistic assessment) which has developed in recent years with great success in optimisation of whole life performance of load bearing infrastructure systems.
Although data from clinical studies of the impact of ECMO on altering the PK of drugs used in patients on ECMO will have great applicability for optimisation of pharmacotherapy, mechanistic research is required to identify the specific factors contributing to these PK changes.
For optimisation, a greater number of cell lines would need to be tested, and an efficient cell-line screening protocol developed.
Finally a more detailed multi-objective optimisation using greater precision is conducted on all variables that exhibit complex behaviour, i.e. which do not take a single value for all optimum solutions.
Since the experimentally determined dependence of the FD response on object and background velocity comprises more data points than the size dependence results (compare [25] with [26]), the former data would have a much greater impact on the optimisation result than the latter data.
Therefore, we have designed and synthesised a novel chemical compound with great potential to further optimisation as inhibitor of drug efflux pumps.
Additionally to biochemical engineering approaches, investigation of cellular processes during viral infection is of great importance for process optimisation.
However, flexible implementation of legacy regulations recognising their primary purpose, rather than slavish adherence to detailed sub-clauses, may achieve greater overall public benefit through optimisation of outcomes across ecosystem services.
