As such, the C282Y variant is associated with greater loss of function compared to the H63D variant, resulting in increased iron transfer in the gut.
These methods use support vector machine (SVM) models, trained on monogenic disease mutations and a control set, and classify each missense SNP as high or low impact on in vivo protein function, where high impact corresponds to approximately a five fold or greater loss of function [ 32, 41].
Mothers experienced the greatest loss of function in relation to work outside the home, while fathers had the most difficulties with participating in social life.
As the greatest loss of function occurs in the first month following TKA [ 19], it is surprising that the ROM therapy during hospital stay is still carried out passively.
We hypothesized that compared to non-progressors, patients who enter stage 3 CKD and ultimately progress have experienced greater loss of renal function, manifested by impairment of metabolic function (anemia, worsening acidosis and mineral abnormalities), than is reflected in the eGFR at entry to stage 3.
Thus, depressed patients may fail to respond to standard medical treatment due to the nature of their mental health problems, and may experience a greater loss of lung function than necessary.
The mean ratio of FEV1 was 0.92 vs 0.77 in controls versus cases, respectively, between pre-9/11 and SPE testing, p<0.001, demonstrating a significantly greater loss of lung function in cases as compared with controls, even when analysed individually.
The rate of pulmonary function decline is directly related to the severity of insulin insufficiency; when followed for 4 years after a baseline OGTT, patients with IGT had a greater loss of lung function than those with NGT, and those with CFRD FH− had the greatest loss (63).
It is important to point out that the notion that type 1 VHL mutants represent a greater loss of VHL function than the type 2B mutations can be viewed as somewhat inconsistent with the fairly equivalent high risk of RCC among types 1 and 2B.
When compared with untreated normal neutrophils, it was noted that neutrophils from septic patients as well as fMLP-treated neutrophils from healthy donors induced significantly greater loss of endothelial barrier function.
Retinal degeneration was also evident in mutants, with greater loss of cone than rod function (Mykytyn et al., 2004; Eichers et al., 2006).
